T cell exhaustion is the dysfunction of T cells caused by prolonged antigen stimulation. In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory signals.

There is a growing interest in reversing or overcoming the state of exhaustion, particularly in the production of CAR-T cells by including checkpoint inhibitor antibodies. The ability to simulate T cell exhaustion problem-solution scenarios is essential to provide further insight into this phenomenon.

This application highlights a multiplexed approach to assessing T cell exhaustion, cell health, and cytokine release in a single well.

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A Live-Cell Analysis platform that supports applications for multiple therapeutic areas

Whether your research field is immunology, oncology, or neuroscience, we offer a wide range of assays, reagents, and consumables specially designed to meet your experimental needs.

Immunology

Our Incucyte® assays for immunology are powerful and flexible tools that allow you to observe and quantitate immune responses in real-time. The automated, live-cell assays, instruments, and user-friendly software simplify data gathering and analysis while maximizing the data you get from each sample.

Oncology

Researchers in oncology need to understand the mechanisms of tumor cell proliferation, metabolism, metastasis, and their avoidance of immune system targeting and destruction. The Incucyte® Live-Cell Analysis System gives you the ability to study cancer cell biology over time and in a completely non-perturbing way.

Neuroscience 

Neuroscientists need assays to understand the neuronal and neuroimmune function, neural cell health and morphology, and neuro-oncology. Get real-time, automated measurements of the dynamic changes and interactions of undisturbed cells in the nervous system from right inside your incubator with the Incucyte® Live-Cell Analysis System.

Introducing Sartorius as your partner for your CAR-T cell therapy discovery and development program

For approval of a CAR-T cell therapy, you need reliable, robust data to meet the necessary efficacy and safety standards. For this, you need to understand your model systems, identify your potential therapeutic targets, and evaluate your corresponding hits at a high level, and as early as possible. Sartorius provides a broad portfolio of comprehensive and complementary solutions to support your CAR-T cell therapy research. Sartorius supports your CAR-T discovery and development program in the following applications:

• In vitro assays
• Sample preparation
• CAR-T cell selection, activation and transduction research
• Cell expansion

Characterization of CAR-T cells, contaminant detection, quality control (QC), and quality assurance (QA)

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