eBook: Organoids and Assembloids in Neuroscience - Stem-cell or Patient-derived 3D cultures, for Modeling Human Brain Development, Functional Networks and Disease
3D culture systems, including stem-cell-derived organoids and assembloids are powerful in vitro tools for recapitulating key features of in vivo systems. Providing efficient platforms in organ development, disease and drug screening studies.
Using these 3D in vitro systems to model highly complex in vivo systems such as the brain, enables investigations which would probably not be possible in in vivo settings, hence they provide valuable insight into human brain functionality and the identification of potential neurological disease drug candidates.
This eBook features reviews, reports, resources, articles and protocols, which highlight current developments in these 3D in vitro platforms, and the benefits of applying these techniques within both basic and translational neuroscience research.
The eBook includes the following topics:
- 3D Models of neuro- and glioblastoma reveal differential pharmacological effects of chemotherapeutic agents
- Advances in microfluidic blood–brain barrier (BBB) models
- Organoid and assembloid technologies for investigating cellular crosstalk in human brain development and disease
- Modeling patient-derived glioblastoma with cerebral organoids
- A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumoral heterogeneity
- Generation of functional human 3D cortico-motor assembloids
- hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids
- Functional characterization of three-dimensional cortical cultures for in vitro modeling of brain networks
- Generation of vascularized neural organoids by co-culturing with mesodermal progenitor cells
- Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin
- Generation of glioblastoma patient-derived organoids and mouse brain orthotopic xenografts for drug screening
