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High Throughput Automated Micro Bioreactor for High Density Fed Batch Strain Selection

Ambr® 15 Fermentation is a high throughput automated bioreactor system for 24 parallel microbial fermentations in a cost-effective 8 –12 mL micro bioreactor format.

It has a wide range of applications in:

  • Strain selection
  • Vector screening
  • Media and feed development
  • Early process optimization
  • QbD and DoE studies
  • Ambr® 15 Fermentation is based on the gold standard Ambr® 15 technology
  • It provides a consistent microscale model for early-stage microbial screening experiments with fed-batch culture capability
  • It offers automated parallel processing and control of 24 bioreactor experiments by one operator
  • Designed to support high-density culture through effective mixing, gassing and fast response to changes in culture parameters
  • Now available with integrated online biomass measurement for real-time continuous growth monitoring of microbial cultures

System Features

    • Online monitoring and closed-loop control of pH, DO and temperature for each bioreactor
    • Culture station control of impeller speed
    • Independent control of gas flow rates (N2, air and O2) for each bioreactor
    • Cascade DO control system for gas flow, stirrer speed and gas mixture
    • Automated liquid handling for bioreactor set-up, feeds, base addition and sampling
    • Software controls and monitors all experiments and records data and events

Ambr® 15 Transforms Early Process Development

  • Provides predictive screening results early in development
  • Enhances scalability over shaken cultures
  • Comparability to benchtop bioreactors
  • Enables data rich culture profiles
  • Increases lab productivity

Ambr® 15 Fermentation Tour

Ambr® 15 Fermentation Vessel Tour

Ambr® 15 Fermentation + Ambr® Analysis Module

The Ambr® Analysis Module enables automated pH measurement, both for initial bioreactor vessel pH sensor calibration and subsequent in-process re-calibration – improving pH control and culture performance.

Learn More About Analysis Module

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