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Biostat® Cplus

The Stainless Steel Fermenter | Bioreactor for Your Laboratory

The Biostat® Cplus is a Sterilizable-In-Place (SIP) Fermenter | Bioreactor developed for the cultivation of microorganisms and cell cultures. Culture vessels with working volumes of 5 L, 10 L, 15 L, 20 L and 30 L are available. With more than a thousand installations worldwide, the Biostat® Cplus is the most successful stainless steel bioreactor of its class and is now available in the revised 3rd generation with DCU controller.

Top Features

∨  Choice between electro or steam heating for operation and sterilization; cost-effective integration into existing infrastructure

∨  Powerful DCU automation platform with newly added functions, e.g. Advanced DO controller, gravimetric feed control and up to four mass flow controllers allowing more sophisticated gassing strategies

∨  Safe to use due to maintenance-free agitator motor and automatic sequences for sterilization and pressure hold test

∨  Compact, mobile design saves valuable laboratory space

Ease of Use, Simple Cleaning and a Space-Saving Design

Innovative Technology for Your Process Needs

Process Step
  • Process development and scale-up
  • Seed production
Vessel Sizes
  • 5 L (benchtop version, only 2:1 ratio)
  • 10 L
  • 15 L
  • 20 L
  • 30 L
Gas Supply Options
Process Analytical Technology
 

Cell Cultivation

Predictive Cultivation with BioPAT® Sensors

Biostat® Cplus + BioPAT® Trace

Biostat® Cplus + BioPAT® Fundalux

Biostat® Cplus + BioPAT® Viamass

  • Inline monitoring of total biomass based on capacitance

Microbial Fermentation

Predictive Cultivation with BioPAT® Sensors

Biostat® Cplus + BioPAT® Xgas

  • High precision of gas flow control by intelligent mass flow controllers
  • Real-time monitoring of exhaust gas is directly available in your Biostat® Cplus
  • Facilitate insights into critical metabolic changes during your fermentation process
  • Ensures optimal growth conditions, ultimately increasing the productivity of your process

Biostat® Cplus + BioPAT® Spectro

  • The fully integrated sensor allows multi-variant bioprocess monitoring
  • Provides real-time feedback on the status of your process
  • Multiple parameter monitoring, e.g., nutrients, metabolites, cell parameters and titers

Biostat® Cplus + BioPAT® Fundalux

  • Enhanced process parameter control with the help of turbidity measurement
  • Greater process understanding of high cell density fermentations
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