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Biostat® D-DCU

Your Fast Lane To Production

The Biostat® D-DCU is a compact bioprocess system available in microbial or cell culture versions with vessel choices from 10 to 200L working volume. The optimized and proven design of the Biostat® D-DCU is the result of thorough analysis of the most required features and functions from over thirty years of stainless steel fermenter | bioreactor design experience. This standardized solution eliminates design times, allows faster delivery, reduces cost, guarantees trouble free operation, allows for global service support as well as spare part availability.

Top Features

  • Designed to interface single-use storage bags for media addition and harvesting, as well as the TAKEONE® single-use aseptic sampling systems
  • Enhanced functionality and ease of use are provided by a wide selection of in-line sensors and analyzers and by integrated display of process values on the DCU screen
  • Due to the modular design, various configurations are available –  from basic to fully featured
  • The system offers an excellent solution for any budget and every need
  • Automated Sterilization in Place (SIP)
  • Automated Cleaning in Place (CIP)
  • Scalable BioPAT® MFCS S88 recipes provide a significant increase in process safety and reliability and result in improved batch-to-batch consistency

Discover the Biostat® D-DCU

Innovative Technology for Your Process Needs

Process Step
  • Process development and scale-up
  • Seed production
  • GMP production
Vessel Sizes

Working Volumes are available in a choice of (2:1 or 3:1 diameter ratio)

  • 10 L
  • 20 L
  • 30 L
  • 50 L
  • 100 L
  • 200 L
Process Analytical Technologies

Gassing Strategies

Applications
  • Microbial and cell culture
  • Suspension and microcarrier cultures

Performance

High-cell density

Employing the Biostat® D-DCU 10-3 it is demonstrated in this study, that this fermenter meets the requirements for an E. coli high-cell density fermentation.

Standardized Qualification of Biostat® D-DCU

The performance capabilities of a bioreactor, which are substantially influenced by its design and thus, its bioengineering characteristics, are crucial in order to choose a system matching the specific process requirements.

In order to guarantee a reliable comparison between existing bioreactor systems the DECHEMA guideline was published by an expert group as a standardized method required for the determination of the key bioengineering data.

Here the Biostat® D-DCU 30-3 and 100-3 are characterized according to this recommendation.

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