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TFF Systems

Process Solutions for Ultrafiltration and Diafiltration

Sartorius offers flexible tangential flow filtration systems for process development and clinical trials in laboratory environments as well as for commercial production batches. Whether you are looking for a cost-efficient multi-use solution or a functionally closed solution with single-use flow paths for aseptic processing, our TFF portfolio offers the right option to meet your individual requirements.

Find the Right TFF System

5 mL – 500 mL

With the Ambr® crossflow, Sartorius offers a high throughput solution for parallel screening. It provides access to molecule behavior at the early development stages.

Attributes Ambr® crossflow 
No of parallel trials  4, 8, 12 or 16
Min recirculation volume 5 ml
Membrane area 10 cm2 
See Product Details
20 mL – 5 L

The Sartoflow® Smart is the ideal crossflow system for process development. Receive the highest product yields with the low shear membrane pump.

Attributes Sartoflow® Smart
Membrane area  50 cm2 – 0.14 m2 
Minimum working volume  <20 mL 
Options available  Yes (e.g., pH, conductivity, temperature sensors) 
See Product Details
2 - 50 L

Process Development / Pre-Clinical 2 – 50 L (20 g 500 g) ​

Sartorius offers flexible TFF solutions to meet your individual requirements. Find the right technology to speed up your process development and for your small-scale production. 

Attributes  CM 150 System Sartoflow® Advanced
Membrane area  0.1 – 0.4 m2 0.1 – 2.1 m2
Minimum working volume <200 mL ~170 mL
Process mode single use Multi use
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20 – 500 L

Qualified and compliant pilot or clinical process scale systems to enable rapid and flexible cGMP scale-up of bioprocesses. 

Attributes CS 1000 System Flexact Modular® C4F
Multi-functional No  Ýes
Recirculation holdup volume Very low  low 
Automation & sensor level Fully process automated Fully process automated
Colorimetric installation guidance HMI & consumables No
Fully self-contained SU fluid contact  No (switch to SC Sartocon) Yes (self-contained Sartocon)
See Product Details See Product Details
’>100-2000L’

Commercial Production 100-2000L (500 g – 20 Kg)

Robust commercial manufacturing scale systems to cover larger throughputs of cGMP single-use biological purification.

Attributes CS 4500 System Flexact Modular® C4F
Multi-functional No  Yes
Recirculation holdup volume Very low  low 
Automation & sensor level Fully process automated Fully process automated
Colorimetric installation guidance HMI & consumables No
Fully self-contained SU fluid contact  No (switch to SC Sartocon) Yes (self-contained Sartocon)
See Product Details See Product Details
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