일정
[웨비나] Meeting Challenging Market Demands: Can Traditional Column Chromatography Be Eliminated? [한국시간 12월 4일 12AM]
기간 : 2020-12-04 ~ 2020-12-04
시간 : 00:00:00 ~ 18:00
Webinar: Meeting Challenging Market Demands: Can Traditional Column Chromatography Be Eliminated?
Date & Time: December 4, 12AM
Presenter
Process intensification is one possibility to meet these goals. In the past, the focus of process intensification was mainly on the upstream side, which pushed the bottlenecks into the downstream area. An important step in DSP is mAb capture. Here the mAb is very specifically captured by a protein A ligand, resulting in >95% of purity. For several decades the default technology has been the use of packed bed column chromatography and diffusion-limited affinity resins. This is a significant pain point in the downstream process, as the flow rate limitations and subsequent underutilization of these resins present considerable investments and process risks for drug manufacturers.
Rapid Cycling Chromatography (RCC) is one way to overcome the limitations of processes based on protein A resins. The development of new chromatographic materials in disposable ready-to-use devices were needed to meet the requirements of RCC, and chromatographic skids had to be adapted to maximize efficiency. The result is a large productivity increase from the mAb capture step and enhanced process flexibility. CoGs are reduced by full utilization of available ligand lifetime, and the one-batch-one-membrane approach significantly reduces key process risks of bioburden and carry-over.
In this exciting webinar, we will present how Sartorius addresses the needs for downstream process intensification with a newly developed Protein A membrane and an optimized RCC skid.
Please register now to reserve your spot and we look forward to welcoming you to our presentation.
Key Learning Objectives
Date & Time: December 4, 12AM
Presenter
- Xindao Mao, Product Manager Chromatography Systems
- Dr. Ricarda Busse, Product Manager Membrane Chromatography
Intensified mAb Capture with Rapid Cycling Chromatography
Two of the key challenges for the biopharmaceutical industry are pressure to reduce costs and uncertainties of drug production, especially in view of the strong competition in the market. To meet these drivers, the industry is looking for ways to cut costs in both the development of new biologics and bulk manufacture. In addition, the facilities must be flexible and able to handle multiple products. Finally, time to clinic and time to market needs to be shortened to ensure market leadership.Process intensification is one possibility to meet these goals. In the past, the focus of process intensification was mainly on the upstream side, which pushed the bottlenecks into the downstream area. An important step in DSP is mAb capture. Here the mAb is very specifically captured by a protein A ligand, resulting in >95% of purity. For several decades the default technology has been the use of packed bed column chromatography and diffusion-limited affinity resins. This is a significant pain point in the downstream process, as the flow rate limitations and subsequent underutilization of these resins present considerable investments and process risks for drug manufacturers.
Rapid Cycling Chromatography (RCC) is one way to overcome the limitations of processes based on protein A resins. The development of new chromatographic materials in disposable ready-to-use devices were needed to meet the requirements of RCC, and chromatographic skids had to be adapted to maximize efficiency. The result is a large productivity increase from the mAb capture step and enhanced process flexibility. CoGs are reduced by full utilization of available ligand lifetime, and the one-batch-one-membrane approach significantly reduces key process risks of bioburden and carry-over.
In this exciting webinar, we will present how Sartorius addresses the needs for downstream process intensification with a newly developed Protein A membrane and an optimized RCC skid.
Please register now to reserve your spot and we look forward to welcoming you to our presentation.
Key Learning Objectives
- Learn more about key challenges in mAb capture
- Find out about different approaches to downstream process intensification
- Understand how optimization of a chromatography skid and the development of a new membrane enables Rapid Cycling Chromatography
- Learn more about reducing process risks with Rapid Cycling Chromatography
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2020-11-25 13:07 ·
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