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Non-Viral Delivery Solutions for Nucleic Acids
Non-viral delivery of nucleic acids for RNA & DNA based therapeutics offer a powerful alternative to viral vector delivery. Complimentary to our range of upstream solutions to produce viral vectors for gene and cell therapies, our non-viral delivery solutions help meet the challenges of in vitro, ex vivo and in vivo gene delivery:
Whether for research or therapeutic applications, Sartorius solutions deliver the flexibility, reliability and efficiency needed to accompany you from initial research to process development and manufacturing.
The gold standard for in vivo delivery of DNA, siRNA/miRNA, shRNA & other oligos:
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A highly efficient, user-friendly alternative to LNPs for in vivo delivery:
Ready-to-use Lipid-based Nanoparticles for Ex Vivo Transfection of Immune and Stem Cells
A novel range of cationic lipids for LNP formulation:
They bring reliability, safety, and cost-efficiency.
An innovative cationic lipid library for efficient and tunable mRNA-LNPs.
Ready-to-use lipid-based nanoparticles solution for delivery of RNA therapeutics.
Novel generation of cationic LNP in the delivery of RNA therapeutics.
Innovative lipid-based delivery solution, unlocking new opportunities in manufacturing genetically modified immune & stem cell therapies.
Innovative cationic lipids fuel next-gen LNPs for targeted oncology and advanced cell therapies.
Learn about a novel lipid library opening new horizons for LNP developers.
With an innovative cationic lipid library.
A novel cationic lipid for LNP formulation.
Join this webinar to understand raw material quality grades and requirements for ATMP manufacturing.
Using a novel lipid library combined with innovative analytical methods.
LipidBrick® LNPs or in vivo-jetRNA®+ can be used in vitro for mRNA validation. However, in vivo-jetPEI® is not suitable for in vitro delivery, and we recommend using jetPEI®. Refer to product ‘Instructions for Use’ for starting conditions.
The route of administration largely affects biodistribution. LipidBrick® Library enables customizable LNP formulation for specific biodistribution. Our cationic solutions tend to target lung and spleen rather than liver. Please contact our technical support team for precise advice polyplus-support@sartorius.com .
The use of commercial mRNA is recommended or purified home-made mRNA with phenol-chloroform and isopropanol, avoiding salt-based methods. Ensure OD260/280 > 2. Chemically 5’ capped and modified mRNA can enhance gene expression.
Sartorius ready-to-use solutions come with a 2-step protocol, ready in 15-20 mins. For LipidBrick® lipids, we recommend either microfluidics, T-junction or ethanol injection. Hand-mixing can also be used, though this may reduce homogeneity of your lipid nanoparticles.
The LipidBrick® Library features proprietary cationic lipids with an imidazolium polar head, designed to offer enhanced safety compared to traditional cationic lipids. We exclusively supply these specific lipids. Additionally, we provide pre-formulated, ready-to-use lipid-based nanoparticle solutions, which serve as alternative delivery methods to lipid nanoparticles (LNPs) for nucleic acid delivery, such as in vivo-jetRNA®+ and LipidBrick® Cell Ready.
Explore high-quality, recombinant, animal-free growth factors and cytokines for ex vivo cell culture.
Xeno-free and animal component-free immune cell media for immunotherapy and immunology research.
Xeno-free and serum-free cell culture media formulations supporting MSCs, iPSCs, HSCs and more.
Utilize our e-Zyvec® assembly technology to design & optimize plasmid sequences tailored to your specific applications.
Discover our plasmid DNA manufacturing services, offering scalable solutions in state-of-the-art GMP facilities.
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