Analyzer Technologies Compatible with Ambr® 15 and Ambr® 250
Integrated and Stand-Alone Analyzers for Key Cell Culture Process Parameters
Ambr® systems have been developed with compatibility to a range of bioprocess analyzer technologies. This can be via integration to the Ambr® system, or via automated transfer of bioreactor sample data and return of analytical results.
Integrated analyzers allow routine measurement of key cell culture process parameters including cell viability, viable cell density and metabolite levels. Analyzers with data-connectivity provide critical quality attribute (CQA) information including product titer, glycosylation levels and cell culture media composition.
Ambr® Analyzer Options
Integrated Analyzers
Ambr® Analysis Module
Ambr® Analysis Module automates pH sensor calibration and BioPAT Spectro applications.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Analysis Module and results returned to the Ambr® software alongside bioreactor process data.
- Initial bioreactor vessel pH sensor calibration
- Analysis temperature matched to bioreactor temperature
- Automated in-process, pH sensor recalibration
Kaiser Optical Systems Raman Rxn2
The Raman Rxn2 automates Raman spectroscopy.
Raman Rxn2 integration is achieved via the BioPAT® Spectro option available for the Ambr® Analysis Module, which transfers bioreactor samples to a flow cell and results returned to the Ambr® software alongside bioreactor process data.
- Supports QbD high-throughput process development
- Enables scale down model building
- Consolidation and contextualization of spectral data with Ambr® bioprocess data
Tornado Spectral Systems HyperFlux PRO 785
The HyperFlux PRO 785 automates Raman spectroscopy.
HyperFlux PRO 785 integration is achieved via the BioPAT® Spectro option available for the Ambr® Analysis Module, which transfers bioreactor samples to a flow cell and results returned to the Ambr® software alongside bioreactor process data.
- Supports QbD high-throughput process development
- Enables scale down model building
- Consolidation and contextualization of spectral data with Ambr® bioprocess data
Nova Biomedical BioProfile® FLEX2
The FLEX2 automates metabolite analysis.
Fully integrated into the Ambr® system, the FLEX2 manages bioreactor samples processing and returns metabolite data to the Ambr® software alongside bioreactor process data.
- Fully automated sample processing, analysis, and reporting
- Individual metabolite data can be used in bioreactor control processes, e.g. glucose additions triggered by low glucose readings
- Simplified data management workflow reduces errors
Roche Cedex HiRes
The Cedex HiRes automates viable cell counting.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Cedex HiRes and results returned to the Ambr® software alongside bioreactor process data.
- Provides total viable cell density and percentage viability
- Allows cell counts to be performed overnight and at weekends
- Results can be used for process control, e.g. samples for product analysis taken once target cell densities are reached
Beckman Vi-CELL™ XR
The Vi-CELL™ XR automates viable cell counting.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Vi-CELL XR for analysis and results returned to the Ambr® software alongside bioreactor process data.
- Provides total viable cell density and percentage viability
- Results can be used for process control, e.g. feed additions calculated and executed based on cell density
- Enables cell counts to be made out of hours without operator attendance
Data Connected Analyzers
Octet® BLI Label-free Detection Systems
The Octet® BLI automates titre and glycan analysis.
Octet® BLI support is achieved via data interfaces facilitating transfer of bioreactor sample data to the analyzer and return of results to the Ambr®. Samples are manually transported between the systems.
- Rapid titer measurement
- Analytes can be measured in crude, unpurified samples
- Relative protein glycosylation levels
Waters™ BioAccord™ LC-MS
The BioAccord™ allows multi-attribute analysis of biological molecules.
BioAccord™ support is achieved via data interfaces facilitating transfer of bioreactor sample data to the analyzer and return of results to the Ambr®. Samples are manually transported between the systems.
- Automation of data acquisition, processing and reporting of complex analytical workflows
- Reduced dependency on core analytical labs
- Analysis of product attributes and cell culture media
Data Analytics
Flexibility – Performance – Quality Assurance
Ambr® Clone Selection powered by Umetrics®
Standalone application designed for use with data from Ambr® systems to simplify the workflow for cell line screening and ranking.
MODDE® Design of Experiment software
The fastest and most cost-efficient way to design effective experiments, increase productivity and de-risk projects.
Related Assets
Related Products
Ambr® 15 Cell Culture
Automated microbioreactor system for cell line development and process optimization, with 24 or 48 single-use 10-15mL microbioreactors.
Ambr® 250 High Throughput
High throughput, automated bioreactor system for process development with 12 or 24 single-use 100–250mL mini bioreactors.
Explore Ambr® 250 High Throughput
Biostat STR®
A range of Analytics and Sensors for Uni-/ Multi-variate Data Gathering: Real Time Monitoring & Control.