State-Of-The-Art Membrane Chromatography Solutions

Achieve Robust Purification Performance With Sartobind Convec Membranes

Ensure high recovery, linear scalability, and superior purity in your purification workflows. Our state-of-the-art membrane chromatography solutions are engineered to meet the demands of modern bioprocessing, helping you enhance productivity through improved yield and selectivity in downstream processing.

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Find the Right Solution

AttributesSartobind® Q GammaSartobind Convec® DSartobind Convec® SC
LigandQuaternary amineDiethylamine (DEAE)Sulfated cellulose
FunctionalityStrong anion exchangeWeak anion exchangeStrong cation exchange, pseudo-affinity
Bed Height | Mode of Operation4 mm and 8mm in flow through and bind | elute8 mm for bind | elute8 mm for bind | elute
Common UseCapture of adenovirus and pDNA and removal of endotoxins and impurities (i.e., DNA and host cell proteins)Purification of lentivirus and extracellular vesicles (i.e., exosomes)Capture of vaccines and VLPs, e.g., influenza, rabies, and encephalitis
Product Format | Membrane VolumeNano (1 mL) to 30" capsule (1.2 L)Nano (3 mL) to 30" capsule (1.2 L)Nano (3 mL) to 30" capsule (1.2 L)
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Sartobind® Q Gamma: Aseptic Bioprocessing Made Easier

  • Short residence times: High-speed purification of 5-30 bed volumes per minute
  • High dynamic binding capacity: More than 10-fold higher binding capacities compared to conventional resins
  • No size exclusion effects: Suitable for large proteins, viruses, and virus-like particles
  • Aseptic processing: Available in gamma-irradiated formats to support closed processing
  • Plug and play: Multiple device formats available, along with your choice of tubing and connectors

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Sartobind Convec® D: Ensure High Recovery, Scalability, and Purity

  • High recovery rates: Achieves more than 60%-80% recovery of infectious lentivirus particles
  • High selectivity and purity: Reduces non-specific binding to maximize yield
  • Short residence times: Increases throughput and productivity with rapid processing
  • Linear scalability: Maintains consistent performance across scales
  • Aseptic processing: Available in gamma-irradiated formats to support closed processing
  • Plug and play: Multiple device formats available, along with tubing and connectors

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Sartobind Convec® SC: Drive Efficiency for Vaccines and Virus-Like Particles

  • High dynamic binding capacity: Enhances process efficiency for large biomolecules
  • High selectivity and purity: Reduces non-specific binding to maximize yield
  • Short residence times: Increases throughput and productivity with rapid processing
  • Linear scalability: Maintains consistent performance across scales
  • Versatility: Compatible with many molecule sizes and types
  • Aseptic processing: Available in gamma-irradiated formats to support closed processing
  • Plug and play: Multiple device formats, tubing, and connectors available

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Supporting Products & Services

mAb Capture with Protein A Membranes

Efficient Protein A membrane chromatography for scalable, faster and cost-effective mAb purification.

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Achieve Gentle Processing With 중공 섬유 Filters

Engineered for gentle handling of sensitive products, 중공 섬유 filters ensure efficiency, care, and optimal performance with every use.

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Sartoflow® Advanced: A Modular Benchtop TFF System

Flexible TFF from process development and clinical trials to small-batch cGMP production.

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Related Assets

적용분야 노트

Enhance LV Purification Performance With Anion-Exchange Chromatography

Read our 적용분야 노트 to discover a scalable, membrane-based method for capturing lentiviral vectors.

Read 적용분야 노트
적용분야 노트

Discover the Value of Membrane Chromatography for Capturing AAVs

The Sartobind® Convec SC is a high-productivity alternative to conventional resins. Read our study to see its performance in an AAV2 process. 

Read 적용분야 노트
Case Study

Quick and Easy Separation of Empty | Full AAV Particles

Sartobind® Q Lab: Achieve 5.3x enrichment in AAV8 purification with high flow rates & effective empty/full separation for all serotypes.

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Frequently Asked Questions

Yes. Our Sartobind® and Sartobind Convec® membrane chromatography portfolio is linearly scalable from small-scale R&D (e.g., Nano, 3 mL) to GMP-grade capsules up to 1,200 mL or more. Since convective flow dominates over diffusive transport, performance remains consistent across scales, reducing the need for re-optimization at larger volumes.

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Sartobind Convec® D is designed for the chromatography capture step in the downstream process of lentivirus production.

Membranes use convective flow, resulting in short residence times and lower 전단응력 compared to resin columns. Also, elution under mild salt conditions (<500–750 mM NaCl) and reduced exposure to process-induced stressors help maintain infective particle integrity.

Our Sartobind Convec® D membranes allow DNA, proteins, and other host cell impurities to flow through, while selectively binding lentivirus particles. This enables a dual function: capture and partial purification in a single step. Sartobind Convec® D showed > 90% 숙주세포 단백질 removal.

Unlike traditional heparin-based resin columns, which have heparin from animal-based origin, Sartobind Convec® SC has a synthetic (chemical) based ligand. It features convection-driven flow, which minimizes diffusion limitations and enables faster processing of large biomolecules and viral particles, making it ideal for virus capture steps in vaccine manufacturing.

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