Streamline Your Antibody Discovery and 선별 with 싸토리우스 Solutions
Therapeutic antibodies are one of the fastest-growing classes of drugs with the promise of better specificity and safety. Successful antibody discovery campaigns take advantage of technologies that allow for rapid identification and characterization of candidate molecules with superior target reactivity and optimized functionality.
The iQue® High-Throughput 선별 (HTS) by Cytometry Platform saves you time, resources, and cost across the biologics discovery workflow.
Click below to see how the iQue® High-Throughput 선별 Cytometry Platform streamlines the three biologics discovery workflow steps antibody 선별, functional profiling, and bioprocessing.
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Reducing Risk, Decreasing Timelines, and Optimizing Outcomes
Get fast and timely access to antibody specificity and species cross reactivity during primary 선별.
Easily go from high content functional assays to actionable information that helps you select candidates with desirable 생리활성.
Select antibody clones upstream of 세포주 development by simultaneously detecting IgG 역가, cell health and viability.
Meet the iQue® HTS cytometry platform, which focuses on speed from setup to acquisition and analysis.
Analyze 역가 & concentration in crude samples, do real-time flexible epitope binning, and screen for CQAs at early stage CLD with Octet® BLI.
Generate the most accurate binding kinetics data in the shortest timeframe imaginable with the Octet® 표면 플라스몬 공명 (SPR) system.
“In-solution, cell-based assays are the way forward and the ability to do so with the iQue® Screener in a 384-well high-throughput format has been extremely useful to us. We can now use one third of the materials and screen 4 times more antibody clones in the same amount of time, obtaining more compelling data for ourselves and our clients.
The i utilizes a unique and rapid, air-gap-delimited sampling technology paired to a no-adjustment, flow-based detection engine and powerful, easy-to-use for assay management and analysis.
Unlike ELISAs, which can only report on binding to single antigens and require large amounts of the target protein to coat entire wells, the is able to simultaneously acquire data on multiple biological readouts and with much less protein. Using differential fluorescent labeling, multiple cell types and a range of cellular parameters can be assessed all in the same well, quickly generating a rich, highly-informative data set. And because multiple target proteins can be presented on beads or on the cell surface, precious reagents are conserved, reducing costs.
Because the supports cell-based assays, target proteins can be presented on the cell surface instead of coated on the wells of a plate. By placing the target in its native conformation, results are more likely to be biologically relevant and better indicators of what will happen .
By sampling only microliters from each well and delivering an air-gap-delimited flow of samples to the detectors, the converts the traditional low throughput, time-consuming 유세포분석 approach into a high throughput process capable of rapidly driving the antibody 선별 process forward. The end result is a data-rich snapshot of the molecular events occurring in each well that can take less than five minutes for a 96-well plate and under 20 minutes for a 384-well plate.
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