Dendritic Cell (DC)Growth Factors and Cytokines
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are able to sensitize T cells to antigens by ingesting structures such as components of microorganisms and presenting them via MHC class II. DCs play a central role in regulating innate and adaptive immunity through innate recognition of pathogens and activation of the adaptive immune response.
Dendritic 세포 치료제 represents a novel and promising immunotherapeutic approach for the treatment of various cancers. A DC-based cancer vaccine is based on the DC-specific ability of presenting antigens to CD4+ and CD8+ T-cells and thus activating the cell-mediated and humoral adaptive immune system against cancer cells.
To ensure a seamless transition from preclinical development to commercial manufacturing, we offer CellGenix® cytokines and growth factors both in GMP and preclinical grade.
Our GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and 밸리데이션 efforts.
CellGenix® GMP recombinant cytokines are produced following all applicable GMP guidelines and allow for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.
Samples for cell and 유전자 치료제 as well as regenerative medicine.
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DC Growth Factors and Cytokines
GM-CSF
IL-4
TNF-α
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IL-1β
IL-6
IFN-γ
IL-10
CellGenix® 재조합 인간 과립구-대식세포 콜로니 자극인자 (GM-CSF, also known as CSF2) is an animal-derived component-free product. It reliably supports the differentiation of CD14+ monocytes into mature dendritic cells (DCs). CellGenix® rh GM-CSF preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
General Information
GM-CSF is an important hematopoietic 성장인자 and immune modulator. It is produced by a variety of cell types including; T cells, macrophages, natural killer cells, endothelial cells and fibroblasts. Its’ role is to promote neutrophil proliferation and maturation.
GM-CSF is used in the cell and 유전자 치료제 space for its ability to promote DC differentiation and function as well as macrophage activity. It is considered a critical factor for the development of DC therapies.
CellGenix® 재조합 인간 인터루킨-4 (IL-4) is an animal-derived component-free product. It reliably stimulates the differentiation of monocytes into dendritic cells (DCs) in combination with GM-CSF. CellGenix® rh Il-4 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
USP Grade
CellGenix® GMP Recombinant Human IL-4 is the reference 표준 for USP Chapter <92> and worldwide the first 사이토카인 that complies with this chapter (USP grade).
IL-4 is a 사이토카인 that plays a key regulator role in humoral and adaptive immune responses. It promotes growth and differentiation of B cells, T cells and cells of the monocytic lineage.
IL-4 is used in the cell and 유전자 치료제 space in combination with GM-CSF for the ex vivo differentiation of monocytes to immature DCs.
CellGenix® 재조합 인간 종양괴사인자-alpha (TNF-α) is an animal-derived component-free product. It reliably stimulates the maturation of immature dendritic cells (DCs). CellGenix® rh TNF-α preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
TNF-α is a proinflammatory 사이토카인 that plays a central role in inflammation, immune system development, 세포자멸사, and lipid metabolism. It is mainly produced by monocytes and macrophages as a response to infection, injury, or tumor burden. TNF-α can also be produced from a range of other cell types such as T cells, natural killer cells (NK cells) and neutrophils.
TNF-α is used in the cell and 유전자 치료제 space for the ex vivo maturation of immature DCs.
CellGenix® 재조합 인간 인터루킨-1 beta (IL-1β) is an animal-derived component-free product. It reliably stimulates the maturation of immature dendritic cells (DCs). It in addition promotes the generation of 거대핵세포 derived from pluripotent stem cells (PSCs). CellGenix® rh IL-1β preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
IL-1β is a proinflammatory 사이토카인 that is mainly produced by monocytes and activated macrophages as a 전단백질. Inflammatory responses are mediated by IL-1β in T cells, natural killer cells (NK cells) and B cells. It induces the production of pro-inflammatory cytokines (IL-2, IL-3, IL-6) as well as interferons. Furthermore, IL-1β modulates the secretion of cytokines by various subsets of human DCs.
CellGenix® IL-1β is used in the cell and 유전자 치료제 space for the ex vivo maturation of immature DCs.
CellGenix® 재조합 인간 인터루킨-6 (IL-6) is an animal-derived component-free product. It reliably stimulates the maturation of immature to mature dendritic cells (DCs) and promotes the proliferation of cord blood derived hematopoietic stem cells (HSCs/CD133+ cells). CellGenix® rh IL-6 preclinical grade and GMP grade are both produced in a dedicated animal-free GMP facility.
IL-6 is a multifunctional 사이토카인 that acts both pro-inflammatory and anti-inflammatory. It regulates acute phase responses, inflammatory reactions, hematopoiesis, bone metabolism, cancer progression and immune responses. It is produced primarily by T cells, monocytes and macrophages.
IL-6 is used in the cell and 유전자 치료제 space for the ex vivo maturation of immature DCs and proliferation of HSCs.
CellGenix® 재조합 인간 인터페론-감마 (IFN-γ) is an animal-derived component-free product. It promotes the maturation of 단핵구-derived dendritic cells (Mo-DCs) and the generation of 사이토카인 induced killer cells (CIK cells). CellGenix® rh IFN-γ preclinical grade is produced in a dedicated animal-free GMP facility ensuring maximum safety for optimal use in ATMP manufacturing.
IFN-γ is a 사이토카인 that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. It is the only member of the type II class of interferons and is predominantly produced by natural killer cells (NK cells) and T cells.
IFN-γ is used in the cell and 유전자 치료제 space for the ex vivo maturation of Mo-DCs, ex vivo generation of CIK cells and stimulation of monocytes, macrophages and microglia.
CellGenix® 재조합 인간 인터루킨-10 (IL-10) is an animal-derived component-free product. It reliably promotes the generation of anti-inflammatory dendritic cells (DCs). CellGenix® rh IL-10 preclinical grade is produced in a dedicated animal-free GMP facility ensuring maximum safety for optimal use in ATMP manufacturing.
IL-10 is an anti-inflammatory 사이토카인, which is classified as a class-2 사이토카인. It amongst others down regulates the expression of T helper 1 cytokines, MHC Class II antigens, and co-stimulatory molecules on macrophages.
IL-10 is used in the cell and 유전자 치료제 space to support the generation of anti-inflammatory DCs.
CellGenix® rh Cytokines - Preclinical vs GMP
Animal-Derived Component-Free (ADCF) Policy
Shipment at Ambient Temperatures
Batch-to-Batch Consistency of CellGenix® GMP Cytokines
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