Immune Cell Media
Human serum and fetal bovine serum have traditionally been used for the expansion of immune cells. However, the associated batch-to-batch variability, risk of contamination by adventitious agents, sourcing challenges, and regulatory complexity pose significant hurdles for 세포 치료제 developers striving to bring their therapies to the clinic. To address these challenges, our immune cell media solutions are designed to eliminate the variability and risks linked to serum-derived components—enabling greater consistency, safety, and regulatory compliance. Explore ourxeno-free and animal component-free media portfolio, specifically developed and optimized for the culture of PBMCs, T cells, CAR-T cells, Tregs, TILs, NK cells, and dendritic cells.
Our animal component-free media formulation eliminates the variability and safety concerns associated with human serum, making it ideal for transition into clinical manufacturing.
Our two chemically 규명된, ready-to-use media (4Cell® Nutri-T GMP Advanced and CellGenix® GMP Advanced TCM) provide excellent performance with both healthy and patient-derived donor cells. Test both media today to find the best fit for your process and cells.
In-house production of critical raw material—recombinant human albumin (Recombumin®)
Regulatory and scientific consultation and assistance
Scale-up and customization capabilities
Research Use Only, GMP available soon
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4Cell® Nutri-T GMP Advanced ®CellGenixGMP Advanced TCM
4Cell® Nutri-T Advanced Medium and CellGenix® Advanced TCM support superior T cells expansion from healthy donor-derived CD3+ T cells compared to alternative chemically 규명된 media after 10-day culture. Viability of T cells is maintained above 90%.
4Cell® Nutri-T Advanced Medium andCellGenix® Advanced TCM support stable CAR expression and high CAR-T cell yield compared to alternative chemically 규명된 media after 10-day culture.
4Cell® Nutri-T Advanced Medium and CellGenix® Advanced TCM support the growth of both CD4+ and CD8+ T cells after 10-day culture. Donor-specific variability in CD4/CD8 ratio is observed.
Cells cultured in 4Cell® Nutri-T Advanced Medium andCellGenix® Advanced TCM display mainly undifferentiated phenotypes in both CD4+ and CD8+ T cells. In contrast, medium supplemented with serum increased the frequencies of effector memory T cells re-expressing CD45RA (Temra).
CAR-T cells cultured for 7 days in our 4Cell® Nutri-T Advanced Medium and CellGenix® Advanced TCM are highly cytotoxic and specifically kill CD19-expressing NALM6 cells.
Patient-derived CAR-T cells expanded better with high viability in 4Cell® Nutri-T Advanced Medium and CellGenix® Advanced TCM.
Stable CAR-expression was maintained and high frequency of CD8 T cells was observed in patient-derived CAR-T cells after 10-day culture in 4Cell® Nutri-T Advanced Medium and CellGenix® Advanced TCM.
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Our serum-free,xeno-free media portfolio is ideal for early-stage research and process development.
Serum-free, xeno-free, ready-to-use medium provides excellent performance with both healthy and patient-derived donor cells.
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Serum-free and xeno-free medium provides exceptional performance with no need to add serum.
Promotes an early-differentiated phenotype
Manufactured in accordance with USP Chapter <1043>, ISO 20399:2022 and all applicable GMP guidelines
FDA Drug Master File (DMF) is available
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4Cell® Nutri-T medium promotes higher IFN-gamma secretion post-co-culturing with 자가유래 patient’s melanoma cells compared to competitor medium + 5% human serum.
4Cell® Nutri-T medium supports a higher expansion rate of healthy PBMCs compared to competitor media.
4Cell® Nutri-T medium supports a higher expansion rate of CAR-T cells compared to competitor media.
4Cell® Nutri-T medium exhibits a high percentage of CD8+ cells in patient-derived cancer cells for TIL processes.
CellGenix® GMP TCM supports greater T cell expansion than other serum-free competitor media while maintaining a high level of viability.
expansion of lentivirus-transduced T cells results in a high proportion of CD19 CAR-T cells in CellGenix® GMP TCM.
CAR-T cells generated with CellGenix® GMP TCM specifically target and kill CD19+ NALM-6 cells with low donor-dependent variance.
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4Cell® Nutri-T: Learn the benefits of a xeno- and serum-free medium for process control and selective expansion of cell subpopulations.
Find out how CellGenix® GMP TCM cell culture media and CellGenix® Cytokines can be used to optimize CAR-T cell manufacturing.
The 싸토리우스 T-Cell Expansion Solution consists of the Biostat® RM TX bioreactor, Flexsafe® RM TX bag, and 4Cell® Nutri-T medium.
This 적용분야 노트 outlines an NK 세포 치료제 production process, covering expansion and functional characterization, including 세포독성, phen...
This 게시물 explores how animal component-free raw materials can enable optimized, reliable, and efficient 세포 치료제 manufacturing.
This 게시물 will explore 공정 집적화 strategies in stirred-tank bioreactors for CAR-T manufacturing.
In this webinar, we showcase the scale-up of a CAR-T perfusion process in stirred-tank bioreactors with automated cell harvesting.
Join this webinar to understand raw material quality grades and requirements for ATMP manufacturing.
Join us with UCL experts to explore how advanced perfusion techniques and stirred-tank bioreactors can overcome CAR-T manufacturing limitations.
Discover methods for growing and enhancing CAR-T cells in automated stirred-bioreactors. Use the best perfusion parameters for optimal results.
In this series, we talk to our media experts about the challenges our customers face in finding suitable media, feeds, and raw materials for their cell culture projects.
In this episode, we talk to our media experts about the challenges in growing and activating T cells and how to overcome these challenges.
In this episode, we talk to our media experts about the applications and flexibility of this T-cell media.
We talk with media experts about the challenges in cell therapies and how CellGenix® GMP DC Medium ensures consistent dendritic cell differentiation.
Target immune cell growth with different combinations of cytokines such as IL-2, IL-7, IL-15 and IL-21
High-quality solutions designed and validated for the cryopreservation and cold storage of cells, including stem cells, T cells, and PBMCs.
싸토리우스 offers a complete scalable bioreactor platform from cell and strain line development to commercial manufacturing.
Utilize our e-Zyvec® assembly technology to design & optimize 플라스미드 sequences tailored to your specific applications.
Explore our lipid library for LNPs and ready-to-use reagents for efficient and cost-effective and nucleic acid delivery.
Multifunctional, high-quality, animal and human-origin-free recombinant human albumin that serves as excipient, ancillary, and raw material.
Combine cell immuno-phenotyping, cell health, and 사이토카인 analysis to quantitate immune cell function
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Select your Nutri-T media type and benefit from our simplified shopping experience.